The disease caused by bacterial infection will require at least two weeks of antibiotic treatment. The medications given can include doxycycline, azithromycin, ofloxacin, ciprofloxacin, levofloxacin or trimethoprim-sulfamethoxazole. Cases caused by Mycobacterium tuberculosis will be treated by anti-tuberculosis medications. General treatment includes bed rest, elevation of scrotum and application of ice. The elevation will raise the scrotal sac above the level of heart improving blood flow and aids in rapid healing. Intake of plenty of water is recommended. Other than these non-steroidal anti-inflammatory drugs such as ibuprofen or naproxen can also be of assistance. If amiodarone is the suspected causes then adjustment of the drug dose is recommended. The severe cases with exaggerated symptoms such as intractable pain, vomiting, very high fever or overall severe illness may require hospital admission. Surgical removal of testis may be required as treatment of epididymitis in complicated cases. In case of chronic illness treatment is mainly directed towards reducing the discomfort.
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